Journal
HETEROCYCLES
Volume 53, Issue 2, Pages 453-+Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/REV-99-526
Keywords
dipyranocoumarin; isolation; classification; conformation; stereochemistry
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Some dipyranocoumarins isolated from Calophyllum genus, Guttiferae (Clusiaceae), show anti HIV-1 activity. The HIV-1 active Calophyllum coumarins such as (+)-calanolide A [(+)-1] and (+)-inophyllum a [(+)-13] have a (2R, 3S, 4S)-2,3-dimethyl-4-chromanol ring as common structural requirements, whereas closely related coumarins were significantly less active or totally inactive. Thus, the stereochemistry of the chromanol ring in Calophyllum coumarins could be responsible for anti HIV-1 activity. Calanolide A [(+)-1] has currently been included in clinical trials. This review describes the distribution, chemistry, and the anti HIV-1 activity of Calophyllum coumarins.
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