Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 25, Issue 2, Pages 70-74Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(99)01525-X
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A tRNA(Lys)-specific anticodon nuclease is kept in a latent form in a rare Escherichia coli strain, complexed with a DNA restriction enzyme. A phage T4 inhibitor of DNA restriction activates anticodon nuclease, but other T4 proteins restore tRNA(Lys). Detection of a homologous system in Neisseria and a different anticodon nuclease in colicin E5 suggest ubiquity and diversity of such tRNA toxins. Analysis of these systems could reveal novel RNA recognition and cleavage mechanisms.
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