Chemiluminescence determination of thioridazine hydrochloride by flow-injection analysis

Hydrogen peroxide, potassium permanganate, potassium dichromate. potassium hexacyanoferrate(III), cerium(IV) sulphate and sodium peroxidisulphate have been tested as potential reagents for chemiluminescence generation from the oxidation of phenothiazine derivatives. Only with potassium permanganale in acidic medium were satisfying results achieved, A total of 13 different phenothiazine derivatives produce luminescence of different intensities on oxidation. Thioridazine hydrochloride was chosen to develop,a rapid and simple method for its determination in pharmaceutical formulations. The limit of detection is 1.2 x 10(-6) mol l(-1), and 110 samples per hour can be determined. (C) 2000 Elsevier Science B.V. All rights reserved.