Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 10, Issue 1, Pages 80-87Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-4388(99)00058-6
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Funding
- NIGMS NIH HHS [GM58801] Funding Source: Medline
- NINDS NIH HHS [NS10655] Funding Source: Medline
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The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated proteins may regulate cell adhesion and actin polymerization, thereby regulating growth cone motility during axonogenesis.
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