Journal
EUROPEAN JOURNAL OF CANCER
Volume 36, Issue 3, Pages 307-313Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0959-8049(99)00312-3
Keywords
breast implants; cancer; epidemiology; foreign bodies; prostheses and implants; risk evaluation; sarcoma
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A meeting was held within the International Agency for Research on Cancer (IARC) Programme on the Evaluation of Carcinogenic Risks to Humans of surgical implants and other foreign bodies. This meeting report summarises the types of materials considered, their wear and degradation, their cancer epidemiology in both humans and other animals, the published experimental carcinogenicity data and selected data oil their toxic, including genotoxic, effects. Evaluations resulting in a classification of Group 2B (possibly carcinogenic to humans) were reached for: (1) polymeric implants prepared as thin smooth films [with the exception of poly (glycolic acid)]; (2) metallic implants prepared as thin smooth films: and (3) implanted foreign bodies consisting of metallic cobalt, metallic nickel and a particular alloy powder consisting of 66-67% nickel, 13-16% chromium and 7% iron. Group 3 classifications (not classifiable as to their carcinogenicity to humans) were made for: (1) organic polymeric materials as a group; (2) orthopaedic implants of complex composition and cardiac pacemakers: (3) silicone breast implants; (3) dental materials: and (5) ceramic implants. (C) 2000 Elsevier Science Ltd. All rights reserved.
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