Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 68, Issue 6, Pages 715-720Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2014.07.010
Keywords
Colorectal cancer; Cytokine-induced killer cells; Immunotherapy; Prognosis
Funding
- Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU
- Priority Academic Program Development of Jiangsu Higher Education Institutions [JX10231801]
- Jiangsu Province Clinical science and technology projects (Clinical Research Center) [BL2012008]
- Summit of the Six Top Talents Program of Jiangsu Province [2013-WSN-034]
Ask authors/readers for more resources
Cytokine-induced killer (CIK) cells are ex vivo generated heterogeneous NK-like T-lymphocytes, which have anti-tumor effects in vitro and in vivo. This present study was conducted to evaluate the effects of autologous CIK cell immunotherapy on the prognosis of colorectal cancer patients. Progression-free survival (PFS), overall survival (OS) and immune cells were assessed. We found that the percentages of CD8(+), CD3(+) CD56(+), CD3 CD56(+) cell subsets were significantly increased from 19.7 +/- 6.3%, 13.8 +/- 7.9%, 1.0 +/- 1.2% to 35.8 +/- 11.6% (P < 0.001), 20.9 +/- 12.5 (P < 0.001), 14.4 +/- 9.5% (P < 0.001), respectively in the CIK group after 14 days of incubation. The median PFS and median OS in the CIK group were 25.8 months and 41.3 months respectively, while 12.0 months and 30.8 months in the control group. The PFS and OS curves of the CIK group and control group indicated that there were also statistically differences between two groups in PFS (log-rank, P = 0.01) and OS (log-rank, P = 0.037). Our results indicate that CIK cell immunotherapy in combination with chemotherapy can reduce the recurrence rate and promote the survival time of patients with colorectal cancer. (C) 2014 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available