Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 10, Issue 1, Pages 78-86Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(99)00053-6
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Crystal structures have recently become available for two proteins (VP39 and elF4E) complexed with their cognate ligand - the mRNA cap, Despite their total structural dissimilarity, both proteins bind N7-methylguanine between two parallel aromatic sidechains, The resulting stacked arrangement governs their high specificity for the alkylated form of the nucleobase.
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