Journal
HUMAN REPRODUCTION
Volume 15, Issue 2, Pages 452-457Publisher
OXFORD UNIV PRESS
DOI: 10.1093/humrep/15.2.452
Keywords
birth weight; intergenerational trends; intrauterine constraint; Macaca mulatta; reproductive health
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Funding
- NIMH NIH HHS [MH 41659, MH 11579-02] Funding Source: Medline
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The gestational experience of a mother can influence the intrauterine environment she pro,ides her own offspring, allowing prenatal events to affect pregnancy outcomes across several generations. Using a multigenerational database, we determined the reproductive consequences for rhesus monkeys descended from small-for-date and large-for-date birth weight matrilines, Both the maternal half-brothers and -sisters of large-for-date infants exhibited enhanced fetal growth, but for small-for-date probands, only the maternal half-sisters experienced significant intrauterine growth constraint In addition, the growth-restricted females were at higher risk of poor reproductive outcomes in adulthood, and they perpetuated the matrilineal birth weight pattern by selectively constraining the fetal development of their daughters, Collectively, these findings suggest a mechanism for the intergenerational persistence of suboptimal pregnancy outcomes.
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