Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 101, Issue 2, Pages 193-198Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S0022-1139(99)00158-X
Keywords
trifluoromethyltrimethylsilane; acylsilanes; difluoro compounds; fluorophenols; terpenes; C-glycosides
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Trifluorotrimethylsilane reacts with acylsilanes to give the corresponding difluoroenoxysilanes via the Brook rearrangement of the alcoholate adducts. The difluoroenoxysilane reacts in situ with various types of electrophilic substrates, leading to gem-difluoro functionalized derivatives in a one-pot methodology. This paper describes reactions with Michael accepters, prenyl, benzyl and glycosyl donors leading to 2,2-difluoro-1,5-diketones, 4,4- or 6,6-difluorocyclohexenones, o- or p-fluorophenols, difluoro analogues of terpenes, and difluoro-C-glycosides. (C) 2000 Elsevier Science S.A. All rights reserved.
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