Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 10, Issue 1, Pages 94-99Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(99)00038-6
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The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53, ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.
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