Journal
BRITISH JOURNAL OF DERMATOLOGY
Volume 142, Issue 2, Pages 338-339Publisher
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2133.2000.03404.x
Keywords
basal cell carcinoma; photodynamic therapy; delta-aminolaevulinic acid; VersaLight (R)
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The incidence of basal cell carcinomas (BCCs) is still increasing, and there is a demand for an easy effective and selective non-invasive treatment such as topical photodynamic therapy (PDT). Twenty-three patients with 24 nodular BCCs were treated once with delta-aminolaevulinic acid (delta-ALA) PDT (100 mW cm(-2), 120 J/cm(2)) 3 weeks after prior debulking of the BCCs. Three months after PDT, all lesions were surgically excised and histopathologically evaluated for residual tumour. Twenty-two (92%) of the 24 nodular BCCs showed a complete response on clinical and histopathological examination. PDT for superficially abraded nodular BCCs with topically applied delta-ALA and the VersaLight(R) as light source is an easy, effective and safe therapy, with excellent cosmetic results and no serious side-effects, in cases where non-surgical treatment of BCCs is indicated.
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