Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 12, Issue 1, Pages 64-76Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(99)00052-7
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Nitric oxide, nitric oxide derivatives and reactive oxygen intermediates are toxic molecules of the immune system which contribute to the control of microbia[ pathogens and tumors. There is recent evidence for additional functions of these oxygen metabolites in innate and adaptive immunity; these functions include the modulation of the cytokine response of lymphocytes and the regulation of immune cell apoptosis, as well as immunodeviating effects. Components of several signal transduction pathways have been identified as intracellular targets for reactive nitrogen and oxygen intermediates.
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