Journal
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
Volume 109, Issue 2, Pages 194-203Publisher
ANNALS PUBL CO
DOI: 10.1177/000348940010900215
Keywords
Botox; botulinum toxin; electromyography; laryngology; larynx; spasmodic dysphonia; voice
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Funding
- NIDCD NIH HHS [Z01 DC 00004] Funding Source: Medline
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To determine the mechanism of symptom relief with treatment by botulinum toxin injection in persons with adductor spasmodic dysphonia (ADSD), we evaluated the effects of unilateral thyroarytenoid muscle injections on both injected and noninjected muscles in 10 subjects with ADSD, using electromyography on bath sides of the larynx before and after treatment. The subjects' speech symptoms were reduced (p = .005) 2 weeks following injection; when the electromyographic study occurred. Muscle activation levels and the numbers of spasmodic muscle bursts decreased significantly (p less than or equal to.03) postinjection in both the injected and noninjected muscles. The reductions in laryngeal muscle bursts correlated with symptom reduction (r greater than or equal to.7) in all muscles. Reductions in laryngeal muscle bursts did not relate to either absolute or normalized levels of muscle activity before or after botulinum toxin injection. The results suggest that changes in the central pathophysiology are responsible for changes in speech symptoms following treatment.
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