Journal
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
Volume 5, Issue 1, Pages 45-52Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bspc.2009.05.001
Keywords
HIV; Nonlinear systems; Parameter identification; Control inputs; Pharmacokinetics; Pharmacodynamics
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Funding
- CNRS-INRIA/MINCyT
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An increasing number of sophisticated control algorithms become available in the current literature to optimize the HIV therapy. Unfortunately, the pharmacokinetics and pharmacodynamics of antiretroviral drugs are ignored and these algorithms remain purely theoretic. This issue is investigated explicitly in this paper. An elementary pharmacodynamics model is combined with a non linear feedback control computed from standard engineering methods. It is shown that it results in the design of a realistic dosage regimen which drives the immunological system close to the healthy equilibrium state. Although the problem is dealt as a single input system, it is argued that the procedure can be extended to a multitherapy design or to any available control law. (C) 2009 Elsevier Ltd. All rights reserved.
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