Journal
JOURNAL OF CELL BIOLOGY
Volume 209, Issue 3, Pages 329-337Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201502062
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Funding
- Marine Biological Laboratories
- David and Lucille Packard Foundation
- National Science Foundation [MCB-1330171, MCB-507511]
- National Institutes of Health/National Institute of General Medical Sciences [GM076094, GM079265]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1330171, 1212400] Funding Source: National Science Foundation
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Many aspects of cytoskeletal assembly and dynamics can be recapitulated in vitro; yet, how the cytoskeleton integrates signals in vivo across cellular membranes is far less understood. Recent work has demonstrated that the membrane alone, or through membrane-associated proteins, can effect dynamic changes to the cytoskeleton, thereby impacting cell physiology. Having identified mechanistic links between membranes and the actin, microtubule, and septin cytoskeletons, these studies highlight the membrane's central role in coordinating these cytoskeletal systems to carry out essential processes, such as endocytosis, spindle positioning, and cellular compartmentalization.
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