Journal
MOLECULAR NEUROBIOLOGY
Volume 21, Issue 1-2, Pages 83-95Publisher
SPRINGER
DOI: 10.1385/MN:21:1-2:083
Keywords
aging; Alzheimer's disease; amyloid; amyotrophic lateral sclerosis; dementia; diabetes; Huntington's disease; Parkinson's disease; prion proteopathy
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The abnormal assembly and deposition of specific proteins in the brain is the probable cause of most neurodegenerative disease afflicting the elderly These cerebral proteopathies include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), prion diseases, and a variety of other disorders. Evidence is accumulating that the anomalous aggregation of the proteins, and not a loss of protein function, is central to the pathogenesis of these diseases. Thus, therapeutic strategies that reduce the production, accumulation, or polymerization of pathogenic proteins might be applicable to a wide range of some of the most devastating diseases of old age.
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