Journal
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Volume 12, Issue 2, Pages 203-208Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00042737-200012020-00012
Keywords
blood ammonia; hepatic encephalopathy; non-absorbable antibiotic; PSE index; rifaximin; treatment
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Objective To determine the efficacy, tolerability and safety of oral rifaximin given at three dose levels in patients with cirrhosis and mild to moderate hepatic encephalopathy (HE), Design prospective double-blind, randomized, parallel-group study. Setting Multi-centre trial in four university teaching hospitals. Participants Fifty-four patients with cirrhosis and mild to moderate HE. intervention Seven days treatment with rifaximin, 600, 1200 or 2400 mg/day in three divided doses, Main outcome measure Change in the portal-systemic encephalopathy (PSE) index between baseline and day 7, calculated on the basis of mental state, asterixis, number connection test time, EEG mean cycle frequency and blood ammonia concentrations, Results Treatment with rifaximin was associated with an improvement in the PSE index. There was a trend towards a greater treatment effect of rifaximin with the highest dose of 2400 mg/day, Rifaximin was well tolerated; the few treatment-related adverse events showed no consistent pattern or dose relationship. Conclusion Rifaximin may be useful as alternative or adjuvant therapy for grade I-III hepatic encephalopathy in patients with cirrhosis at a dose of 1200 mg/day. Eur J Gastroenterol Hepatol 12:203 - 208 (C) 2000 Lippincott Williams & Wilkins.
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