Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 57, Issue 2, Pages 276-289Publisher
SPRINGER BASEL AG
DOI: 10.1007/PL00000690
Keywords
proteoglycan; chondroitin sulfate; extracellular matrix; nervous system; neurite outgrowth; axon regeneration
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Funding
- NICHD NIH HHS [HD 25938] Funding Source: Medline
- NINDS NIH HHS [NS 32717] Funding Source: Medline
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Lecticans are a family of chondroitin sulfate proteoglycans, encompassing aggrecan, versican, neurocan and brevican. These proteoglycans are characterized by the presence of a hyaluronan-binding domain and a C-type lectin domain in their core proteins. Through these domains, lecticans interact with carbohydrate and protein ligands in the extracellular matrix and act as linkers of these extracellular mall ix molecules. In adult brain, lecticans are thought to interact with hyaluronan and tenascin-li to form a ternary complex. We propose that the hyaluronan-lectican-tenascin-R complex constitutes the core assembly of the adult brain extracellular matrix, which is found mainly in pericellular spaces of neurons as 'perineuronal nets'.
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