Journal
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
Volume 89, Issue 2, Pages 111-118Publisher
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1016/S1389-1723(00)88723-X
Keywords
hydroxylation; carboxylation; aromatic N-heterocycles
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Aromatic N-heterocycles are common structural motifs and versatile building blocks for the synthesis of various biologically active compounds. The application of microbial catalysis is considerably advantageous for the synthesis of N-heterocycle derivatives. Recent progress in the microbial functionalization of aromatic N-heterocyclic compounds is reviewed, focusing on the regiospecific hydroxylation and the carboxylation of aromatic N-heterocycles.
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