Journal
JOURNAL OF CELL BIOLOGY
Volume 210, Issue 7, Pages 1075-1083Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201503115
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Funding
- Herchel Smith Postdoctoral Fellowship
- Wellcome Trust
- National Institutes of Health grants [EY14358, EY01730]
- Medical Research Council Career Development Award
- Human Frontier Science Program Young Investigator Grant
- MRC [G1100312] Funding Source: UKRI
- Medical Research Council [G1100312] Funding Source: researchfish
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To investigate the cellular basis of tissue integrity in a vertebrate central nervous system (CNS) tissue, we eliminated Muller glial cells (MG) from the zebrafish retina. For well over a century, glial cells have been ascribed a mechanical role in the support of neural tissues, yet this idea has not been specifically tested in vivo. We report here that retinas devoid of MG rip apart, a defect known as retinoschisis. Using atomic force microscopy, we show that retinas without MG have decreased resistance to tensile stress and are softer than controls. Laser ablation of MG processes showed that these cells are under tension in the tissue. Thus, we propose that MG act like springs that hold the neural retina together, finally confirming an active mechanical role of glial cells in the CNS.
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