Journal
BIOMEDICAL MICRODEVICES
Volume 16, Issue 5, Pages 673-679Publisher
SPRINGER
DOI: 10.1007/s10544-014-9871-3
Keywords
Surface enhanced Raman scattering (SERS); Folic acid; Methotrexate
Funding
- NSF CAREER Award [1055932]
- MRI Award [1229635]
- Wayne State University
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1055932] Funding Source: National Science Foundation
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [1229635] Funding Source: National Science Foundation
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A highly sensitive surface enhanced Raman scattering (SERS) substrate with particle-film sandwich geometry has been developed for the label free detection of folic acid (FA) and methotrexate (MTX). In this sandwich structure, the bottom layer is composed of a copper foil decorated with silver nanoparticles synthesized by the galvanic displacement reaction, and top layer is constituted by silver nanoparticles. The FA and MTX molecules are sandwiched between the silver nanoparticles decorated copper film and the silver nanoparticles. The plasmonic coupling between the two layers of the sandwich structure greatly enhances the SERS spectra of FA and MTX. SERS activity of the substrate was studied and optimized by adjusting the time of galvanic displacement reaction. The SERS spectra of the FA and MTX showed the minimum detection concentration of 100 pM. The identification of methotrexate and folic acid analogs was also carried out by SERS spectra analysis.
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