Journal
JOURNAL OF CONTROLLED RELEASE
Volume 63, Issue 3, Pages 235-259Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-3659(99)00204-7
Keywords
intragastric floating systems; hydrodynamically balanced systems; gastroretentive systems; microballoons; buoyant delivery systems
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In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed. (C) 2000 Elsevier Science B.V. All rights reserved.
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