Journal
BIOMEDICAL MICRODEVICES
Volume 14, Issue 4, Pages 651-657Publisher
SPRINGER
DOI: 10.1007/s10544-012-9641-z
Keywords
Encoded microparticles; Microarray; Immunoassay; Bead-based
Funding
- European Union
- Engineering and Physical Sciences Research Council [GR/S23513/01] Funding Source: researchfish
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A multiplexed suspension array platform, based on SU8 disks patterned with machine-readable binary identification codes is presented. Multiple probe molecules, each attached to individual disks with different unique codes, provide multiplexed detection of targets in a small sample volume. The experimental system consists of a microfluidic chamber for arraying the particles in a manner suitable for high throughput imaging using a simple fluorescent microscope, together with custom software for automated code readout and analysis of assay response. The platform is demonstrated with a multiplexed antibody assay targeting 3 different human inflammatory cytokines. The suitability of the platform for other bio-analytical applications is discussed.
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