Journal
BIOMEDICAL MICRODEVICES
Volume 15, Issue 2, Pages 289-297Publisher
SPRINGER
DOI: 10.1007/s10544-012-9729-5
Keywords
Acoustic radiation pressure; Particle patterning; 2D particle manipulation; Sonotweezers
Funding
- University of Bristol
- University of Southampton
- University of Dundee
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We describe the construction of an ultrasonic device capable of micro-patterning a range of microscopic particles for bioengineering applications such as targeted drug delivery. The device is formed from seven ultrasonic transducers positioned around a heptagonal cavity. By exciting two or three transducers simultaneously, lines or hexagonal shapes can be formed with microspheres, emulsions and microbubbles. Furthermore, phase control of the transducers allows patterning at any desired position in a controlled manner. The paper discusses in detail direct positioning of functionalised microspheres, emulsions and microbubbles. With the advantages of miniaturization, rapid and simple fabrication, ultrasonic tweezers is a potentially useful tool in many biomedical applications.
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