Journal
FEBS LETTERS
Volume 467, Issue 1, Pages 7-11Publisher
WILEY
DOI: 10.1016/S0014-5793(00)01111-X
Keywords
NDST-1; disruption; atelectasis; type II pneumocyte; immaturity; respiratory distress syndrome
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In order to address the biological function of GlcNAc N-deacetylase/N-sulfotransferase-1 (NDST-1), we disrupted the NDST-1 gene by homologous recombination in mouse embryonic stem cells. The NDST-1 null mice developed respiratory distress and atelectasis that subsequently caused neonatal death, Morphological examination revealed type II pneumocyte immaturity, which was characterized by an increased glycogen content and a reduced number of lamellar bodies and microvilli. Biochemical analysis further indicated that both total phospholipids and disaturated phosphatidylcholine were reduced in the mutant lung, Our data revealed that NDST-1 was essential for the maturation of type II pneumocytes and its inactivation led to a neonatal respiratory distress syndrome. (C) 2000 Federation of European Biochemical Societies.
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