Journal
BIOMEDICAL MICRODEVICES
Volume 13, Issue 3, Pages 527-532Publisher
SPRINGER
DOI: 10.1007/s10544-011-9521-y
Keywords
Cell lysis; Titanium dioxide; UV; Microchip; Lab-on-a-Chip
Funding
- National Sciences and Engineering Research Council of Canada (NSERC)
- University of Waterloo
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In this paper, a novel method is proposed and demonstrated to be able to lyse gram-negative (E. coli) bacteria cells for Lab-on-a-Chip applications. The proposed method incorporates using titanium dioxide particles as photocatalysts and a miniaturized UV LED array as an excitation light source to perform cell lysis on microchips. The experimental result demonstrates the feasibility of the proposed prototype device. The working device suggests an inexpensive, easy to be fabricated and effective way for microchip cell lysis. The miniaturized UV LED array and the microchip with a reaction chamber can be easily integrated with other functional components to form a customized whole Lab-on-a-Chip system.
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