4.5 Article

Bioisosteric modification of PETT-HIV-1 RT-inhibitors:: Synthesis and biological evaluation

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 10, Issue 3, Pages 265-268

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(99)00675-7

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Bioisosteric substitution of the thiourea (3, 5, 7, 9) and urea (10) moiety of PETT compounds with sulfamide (1), cyanoguanidine (2, 4) and guanidine (6, 8) functionalities, and replacement of the phenethyl group with benzoylethyl group (compounds 11-20) have been studied. Synthesis and antiviral activities are described. (C) 2000 Elsevier Science Ltd. All rights reserved.

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