Journal
BIOMEDICAL MICRODEVICES
Volume 13, Issue 2, Pages 345-352Publisher
SPRINGER
DOI: 10.1007/s10544-010-9498-y
Keywords
FET; CMOS; MEMS; Glycated hemoglobin (HbA1c); Hemoglobin
Funding
- State Hi-tech Research and Development Program (863 Program) of China [2006AA04Z366]
- National Basic Research Program of China (973 Program) [2009CB320300]
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A field effect transistor (FET)-based immunosensor was developed for diabetes monitoring by detecting the concentrations of glycated hemoglobin (HbA1c) and hemoglobin (Hb). This immunosensor consists of a FET-based sensor chip and a disposable extended-gate electrode chip. The sensor chip was fabricated by standard CMOS process and was integrated with signal readout circuit. The disposable electrode chip, fabricated on polyester plastic board by Micro-Electro-Mechanical-Systems (MEMS) technique, was integrated with electrodes array and micro reaction pool. Biomolecules were immobilized on the electrode based on self-assembled monolayer and gold nanoparticles. Experimental results showed that the immunosensor achieved a linear response to HbA1c with the concentration from 4 to 24 mu g/ml, and a linear response to Hb with the concentration from 60 to 180 mu g/ml.
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