Journal
JOURNAL OF CELL BIOLOGY
Volume 210, Issue 5, Pages 851-864Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201412074
Keywords
-
Categories
Funding
- Human Frontiers Science Program Young Investigator Award [RGY0074/2008]
- National Institutes of Health [R01GM100114, 5R01AI097202]
- New Mexico Spatiotemporal Modeling Center grant [P50GM085273]
- Netherlands Organization for Scientific Research (NWO) [836-09-002, 680-47-421]
- NWO Medium Sized Investment NWO-ZonMW [91110007]
- Grants-in-Aid for Scientific Research [25253071] Funding Source: KAKEN
Ask authors/readers for more resources
Mast cells (MCs) produce soluble mediators such as histamine and prostaglandins that are known to influence dendritic cell (DC) function by stimulating maturation and antigen processing. Whether direct cell-cell interactions are important in modulating MC/DC function is unclear. In this paper, we show that direct contact between MCs and DCs occurs and plays an important role in modulating the immune response. Activation of MCs through FceRI cross-linking triggers the formation of stable cell-cell interactions with immature DCs that are reminiscent of the immunological synapse. Direct cellular contact differentially regulates the secreted cytokine profile, indicating that MC modulation of DC populations is influenced by the nature of their interaction. Synapse formation requires integrin engagement and facilitates the transfer of internalized MC-specific antigen from MCs to DCs. The transferred material is ultimately processed and presented by DCs and can activate T cells. The physiological outcomes of the MC-DC synapse suggest a new role for intercellular crosstalk in defining the immune response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available