Journal
NEUROLOGY
Volume 54, Issue 3, Pages 647-653Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.54.3.647
Keywords
corpus callosum; traumatic brain injury; children
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Funding
- NCRR NIH HHS [M01-RR02558] Funding Source: Medline
- NINDS NIH HHS [NS21889] Funding Source: Medline
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Objective: To study effects of closed head injury (CHI) severity on development of corpus callosum (CC) in children, using MRI. Background: Vulnerability of CC to diffuse axonal injury has been shown in adults and children by neuropathologic and MRI studies. Given continued development of CC through the second decade, serial MRI could characterize effects of CHI on CC growth in children. Methods: MRI performed at 3 and 36 months after severe (mean age = 10.3 years, n = 25) and mild to moderate (mean age = 9.7 years, n = 28) CHI. Mild to moderate and severe CHI groups did not differ in demographic features. Morphometry of T1-weighted midsagittal CC by two operators with satisfactory interrater reliability yielded uncorrected and corrected CC volume. Results: An interaction of occasion with CW severity was present as CC area decreased from 3 to 36 months in severely injured children and increased in the mild to moderate CHI group. Uncorrected CC area was correlated with acute CHI severity and functional outcome at 36 months postinjury. Conclusions: Morphometric measurement of CC area provides a useful index of diffuse injury, which is related to functional outcome of CHI in children.
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