Journal
BIOMEDICAL MICRODEVICES
Volume 13, Issue 1, Pages 231-242Publisher
SPRINGER
DOI: 10.1007/s10544-010-9488-0
Keywords
Flow optimization; Microfluidic; Positron emission tomography; Fluorescence imaging; Microreactor; Numerical modeling
Funding
- Siemens Molecular Imaging, Biomarker Research, Culver City, CA
- Institute for Collaborative Biotechnologies, U.S. Army Research Office [W911NF-09-D-0001]
Ask authors/readers for more resources
We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reaction chamber. Numerical solutions of the general incompressible Navier Stokes equations along with time-dependent elution scalar field equation for the three dimensional coin-shaped geometry were obtained and validated using fluorescence imaging analysis techniques. Utilizing the approach presented in this work, we were able to identify optimized geometrical and operational conditions for the micro-reactor in the absence of radioactive material commonly used in PET related tracer production platforms as well as evaluate the designed and fabricated micro-reactor using numerical and experimental validations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available