Journal
BIOMEDICAL MICRODEVICES
Volume 12, Issue 1, Pages 35-40Publisher
SPRINGER
DOI: 10.1007/s10544-009-9355-z
Keywords
Cell electroporation; Microfluidics; Hydrodynamic focusing
Funding
- National Basic Research Program [2007CB935602]
- NSFC [90607004, 10672005, 10872008, 10634010, 10704002]
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Microfluidics-based cell electroporation has many advantages in delivering small molecules into cells. In this study, hydrodynamic focusing of fluids with different conductivities has been used for high through-put cell electroporation at low voltage (<3 V) of continuous direct current (dc) power. Simulation results showed that an input voltage of only 1.5 V could generate an electric field intensity of about 1.17 kV cm(-1) across the cell suspension flow in the squeezed area. The electropermeation of yeast cell was observed, showing a permeabilization percentage up to 70%.
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