Journal
BIOMEDICAL MICRODEVICES
Volume 11, Issue 3, Pages 625-631Publisher
SPRINGER
DOI: 10.1007/s10544-008-9272-6
Keywords
MEMS; Drug delivery; Trauma care; Emergency; Micro-implant; Rapid delivery; Ambulatory emergency care; Cardiac device; Bolus; Subcutaneous; Cardiac
Funding
- Army Research Office support via the Institute for Soldier Nanotechnologies (ISN) at MIT [W911NF-07-D-0004]
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We introduce the first implantable drug delivery system based on MEMS (Micro-Electro-Mechanical-Systems) technology specifically designed as a platform for treatment in ambulatory emergency care. The device is named IRD(3) (implantable rapid drug delivery device) and allows rapid delivery of drugs. Vasopressin was used as a model drug for in vitro tests as it is a commonly used drug for cardiac resuscitation. Experimental results reveal that the IRD(3) provides an effective method for rapid delivery without significant drug degradation. Several medical uses and delivery modalities for IRD(3) are proposed.
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