Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 65, Issue 3, Pages 767-774Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo991328h
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- NIGMS NIH HHS [GM-46059] Funding Source: Medline
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Kinetic resolution of the N-methyl imines of 3-substituted indanones and 4-substituted tetralones could be accomplished by hydrosilylation with a chiral titanocene catalyst. N-Methyl imines of 4-substituted tetralones were resolved to yield, after hydrolysis of the unreacted starting materials, ketones with high ee's and the amine products with high diastereomeric and enantiomeric purity. The utility of this process was demonstrated in the synthesis of sertraline.
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