Journal
FEBS LETTERS
Volume 467, Issue 2-3, Pages 359-364Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01170-4
Keywords
polyomavirus; VPI; nuclear matrix; Yin Yang 1
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Polyomavirus reaches the nucleus in a still encapsidated form, and the viral genome is readily found in association with the nuclear matrix, This association is thought to be essential for viral replication. In order to identify the protein(s) involved in the virus-nuclear matrix interaction, we focused on the possible roles exerted by the multifunctional cellular nuclear matrix protein Yin Yang 1 (YY1) and by the viral major capsid protein VP1, In the present work we report on the in vivo association between YY1 and VP1, Using the yeast two-hybrid system we demonstrate that the VPI and YY1 proteins physically interact through the D-E region of VP1 and the activation domain of YY1. (C) 2000 Federation of European Biochemical Societies.
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