Journal
BIOMEDICAL MICRODEVICES
Volume 11, Issue 1, Pages 243-249Publisher
SPRINGER
DOI: 10.1007/s10544-008-9230-3
Keywords
Chitosan; Microsphere; Monodispersed; Microfluidic device; BSA
Funding
- National Natural Science Foundation of China [20525622, 20676066, 20806042]
- National Basic Research Program of China [2007CB714302]
Ask authors/readers for more resources
This work describes a novel microfluidic method to prepare monodispersed chitosan microspheres by using the solvent extraction method. Our strategy is that a chitosan/acetic acid aqueous solution is emulsified in an organic phase containing the extractant by using the co-flowing shear method in a co-axial microfluidic device. The formed droplets are in situ solidified within a synthesizing channel by the extraction of acetic acid from the chitosan aqueous droplets to the organic solution. Based on this approach, the size of chitosan microspheres can be successfully controlled from 100 mu m to 700 mu m in diameter with a variation of less than 4%. Furthermore, high loading efficiency (> 95%) of Bovine serum albumin (BSA) can be in situ encapsulated. The present method has the advantages of actively controlling the droplet diameter, narrow size distribution, good sphericity, and having a simple and low cost process, with a high throughput. This approach for the preparation of chitosan microspheres will provide many potential applications for pharmaceutical area.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available