Journal
BIOMEDICAL MATERIALS
Volume 13, Issue 6, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1748-605X/aae15b
Keywords
collagen; silver nanoparticles; anti-bacterial; anti-inflammation; guide bone regeneration
Funding
- Australia Research Council Linkage Grant [LP150100905]
- Australian Research Council Industrial Transformation Training Centre for Personalised Therapeutics Technologies [IC170100016]
- Australian Research Council Industrial Transformation Training Centre for Personalized Therapeutics Technologies [IC170100016]
- National Natural Science Foundation of China [81802214]
- MedTech and Pharma Growth Centre
- Guangdong Science and Technology Department [2015B020225007]
- Centre for Microscope Characterization and Analysis (CMCA) at the University of Western Australia
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Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering. The optimized AgNP-coated collagen membrane exhibited excellent anti-bacterial effects against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) with limited cellular toxicity. It also displayed effective anti-inflammatory effects by reducing the expression and release of inflammatory cytokines including IL-6 and TNF-alpha. Additionally, AgNP-coated collagen membranes were able to induce osteogenic differentiation of mesenchymal stem cells that guide bone regeneration. These findings demonstrate the potential application of AgNP- coated collagen membranes to prevent infection after bone graft introduction in alveolar ridge reconstruction.
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