Journal
BIOMEDICAL MATERIALS
Volume 9, Issue 2, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1748-6041/9/2/025011
Keywords
Mg-Zn alloy; degradable; in vivo; healing; angiogenesis
Funding
- National Natural Science Foundation of China [30901422, 51271117]
- Shanghai Jiao Tong University Interdisciplinary (Biomedical Engineering) Research Fund [YG2010MS45]
- Shanghai Jiao Tong University School of Medicine Science and Technology Fund [09XJ21005]
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To evaluate the different effects of Mg-6Zn alloy and Ti-3Al-2.5V alloy implants in intestinal tract healing, we compared these two different alloys with respect to their effect on a rat's intestinal tract, using serum magnesium, radiology, pathology and immunohistochemistry in vivo. It was found using the scanning electron microscope that the Mg-6Zn alloy began to degrade during the first week and that the Ti-3Al-2.5V alloy was non-degradable throughout the process. The Mg-6Zn alloy did not have an impact on serum magnesium. Superior to the Ti-3Al-2.5V alloy, the Mg-6Zn alloy enhanced the expression of transforming growth factor-beta 1 in healing tissue, and promoted the expression of both the vascular endothelial growth factor and the basic fibroblast growth factor, which helped angiogenesis and healing. The Mg-6Zn alloy reduced the expression of the tumor necrosis factor (TNF-alpha) at different stages and decreased inflammatory response, which may have been related to the zinc inhibiting TNF-alpha. In general, the Mg-6Zn alloy performed better than Ti-3Al-2.5V at promoting healing and reducing inflammation. The Mg-6Zn alloy may be a promising candidate for use in the pins of circular staplers for gastrointestinal reconstruction in medicine.
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