Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 97, Issue 4, Pages 1695-1700Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.97.4.1695
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Funding
- NCI NIH HHS [R01 CA046465, 1P30-CA72720, R01-CA46465, P30 CA072720] Funding Source: Medline
- NIAID NIH HHS [R01 AI043369, R01 AI036450, R01 AI36450] Funding Source: Medline
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We identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which we designated cmvlL-10, cmvlL-10 can bind to the human IL-10 receptor and can compete with human IL-10 for binding sites, despite the fact that these two proteins are only 27% identical. cmvlL-10 requires both subunits of the IL-10 receptor complex to induce signal transduction events and biological activities. The structure of the cmvlL-10 gene is unique by itself. The gene retained two of four introns of the IL-10 gene, but the length of the introns was reduced. We demonstrated that cmvlL-10 is expressed in CMV-infected cells. Thus, expression of cmvlL-10 extends the range of counter measures developed by CMV to circumvent detection and destruction by the host immune system.
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