Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 374, Issue 2, Pages 334-338Publisher
ACADEMIC PRESS INC
DOI: 10.1006/abbi.1999.1605
Keywords
-
Categories
Funding
- NIDDK NIH HHS [DK14881] Funding Source: Medline
Ask authors/readers for more resources
In addition to its role in calcium and skeletal homeostasis, there is increasing evidence that the hormonal form of vitamin D-,D- 1,25-dihydroxyvitamin D-3, appears to serve as a modulator of the immune system. We have determined the level of the 1,25-dihydroxyvitamin D-3 receptor (VDR) in resting and activated lymphocytes by immuno- and ligand-binding assays. As expected from previous work, the total T lymphocyte population contains VDR whose levels are increased when activated and treated with 1,25-dihydroxyvitamin D-3. Surprisingly, the highest concentrations of VDR are found in CD8 lymphocytes, although significant amounts are also present in CD4 lymphocytes. Furthermore, B lymphocytes do not contain detectable amounts of VDR. Cells of the monocyte/macrophage lineage possess small amounts of VDR that are not affected by activation but are increased by treatment with 1,25-dihydroxyvitamin D-3. These results suggest that CD8 lymphocytes may be a major site of 1,25-dihydroxyitamin D-3 action, while B lymphocytes are likely not directly regulated by 1,25-dihydroxyvitamin D-3. (C) Academic Press.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available