Journal
JOURNAL OF CELL BIOLOGY
Volume 209, Issue 1, Pages 11-12Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201503079
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- NIGMS NIH HHS [T32 GM008320] Funding Source: Medline
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A migrating cell must establish front-to-back polarity in order to move. In this issue, Juanes-Garcia et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201407059) report that a short serine-rich motif in nonmuscle myosin IIB is required to establish the cell's rear. This motif represents a new paradigm for what determines directional cell migration.
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