The synthesis of unsymmetrical S1-(3′-O-thymidine-O-methanephosphonyl)-S2-p-nitrophenyl disulfides and their reactions with triphenylphosphine

The reaction of thymidine 3'-methanephosphonothioic acid with p-nitrophenylsulfenyl chloride provides S-1 -(3'-O-thymidine-O-methanephosphonyl)-S-2-p-nitrophenyl disulfide which, in the presence of an excess of sulfenyl chloride and triphenylphosphine gives, in a stereospecific manner, thymidine 3'-(S-p-nitrophenyl methanephosphonodithioate). (C) 2000 Elsevier Science Ltd. All rights reserved.