Journal
JOURNAL OF CELL BIOLOGY
Volume 148, Issue 4, Pages 635-651Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.148.4.635
Keywords
nuclear pore complex; nucleoporins; nucleocytoplasmic transport; mass spectrometry; proteomics
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Funding
- NCRR NIH HHS [RR00862, U54 RR022220] Funding Source: Medline
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An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic exchange requires a comprehensive inventory of the molecular components of the NPC and a knowledge of how each component contributes to the overall structure of this large molecular translocation machine, Therefore, we have taken a comprehensive approach to classify all components of the yeast NPC (nucleoporins),This involved identifying all the proteins present in a highly enriched NPC fraction, determining which of these proteins were nucleoporins, and localizing each nucleoporin within the NPC, Using these data, we present a map of the molecular architecture of the yeast NPC and provide evidence for a Brownian affinity gating mechanism for nucleocytoplasmic transport.
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