Journal
VACCINE
Volume 18, Issue 16, Pages 1624-1628Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(99)00497-1
Keywords
aging; immunology; repertoire
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Funding
- NIA NIH HHS [AG 14669, AG 08707] Funding Source: Medline
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Changes in the B-cell repertoire during aging include a shift in antibody specificities from foreign to autologous antigens associated with a decline in the activity of conventional B2. compared to B1 lymphocytes. The age-associated increase in B1 lymphocyte number and activity contribute to the increased serum concentration of autoantibodies and the B-cell clonal expansions that develop with age. Aging is also associated with a decreased diversity of the antibody response reflected in the preferential loss of IgG and high affinity antibodies following immunization with a foreign antigen. Many of these changes can be traced to an impaired capacity of T cells to support isotype switching and somatic mutation in the periphery and the generation of a diverse B-cell repertoire from bone marrow B-cell precursors, (C) 2000 Elsevier Science Ltd. AII rights reserved.
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