Journal
EXPERIMENTAL CELL RESEARCH
Volume 255, Issue 1, Pages 114-124Publisher
ELSEVIER INC
DOI: 10.1006/excr.1999.4767
Keywords
H1-deficient mice; linker histones; spermatogenesis; chromatin structure
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The linker histone subtype H1.1 belongs to the group of main-type histones and is synthesized in somatic tissues as well as in germ cells during the S phase of the cell cycle. In adult mice the histone gene H1.1 is expressed mainly in thymus, spleen, and testis. The single-copy gene coding for the H1.1 protein was eliminated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the deficient H1.1. gene developed normally until the adult stage without H1.1 mRNA and H1.1 protein. No anatomic abnormalities could be detected. In addition, mice lacking the H1.1 gene were fertile and they showed normal spermatogenesis and testicular morphology. (C) 2000 Academic Press.
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