Journal
NEUROSCIENCE LETTERS
Volume 280, Issue 3, Pages 167-170Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(00)00798-9
Keywords
repetitive transcranial magnetic stimulation; verbal working memory; positron emission tomography; functional lesion; dorsolateral prefrontal cortex; regional cerebral blood flow
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We studied the effect of repetitive transcranial magnetic stimulation (rTMS) on changes in regional cerebral blood flow (rCBF) as revealed by positron emission tomography (PET) while subjects performed a 2-back verbal working memory (WM) task. rTMS to the right or left dorsolateral prefrontal cortex (DLPFC), but not to the midline frontal cortex, significantly worsened performance in the WM task while inducing significant reductions in rCBF at the stimulation site and in distant brain regions. These results for the first time demonstrate the ability of rTMS to produce temporary functional lesions in elements of a neuronal network thus changing its distributed activations and resulting in behavioral consequences. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.
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