Journal
NEUROREPORT
Volume 11, Issue 3, Pages 541-544Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200002280-00023
Keywords
antioxidant potential; brain; central nervous system; lipid peroxidation; methylmalonic acid; propionic acid; oxidative stress; rat
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The in vitro effects of propionic and L-methylmalonic acids on some parameters of oxidative stress were investigated in the cerebral cortex of 21-day-old rats. Chemiluminescence, thiobarbituric acid-reactive substances (TBA-RS) and total radical-trapping antioxidant capacity (TRAP) were measured in brain tissue homogenates in the presence of propionic or L-methylmalonic acids at concentrations ranging from I to 10 mM. Both acids significantly increased chemiluminescence and TBA-RS and decreased TRAP, indicating a simulation of lipid peroxidation and a reduction of tissue antioxidant potential. Other organic acids tested which accumulate in some organic acidemias (suberic, sebacic, adipic, 3-methylglutaric and 4-hydroxybutyric acids) did not affect these parameters. This study provides evidence: that free radical generation may participate in the neurological dysfunction of propionic and methylmalonic acidemias. NeuroReport 11:541-544 (C) 2000 Lippincott Williams & Wilkins.
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