Journal
HORMONE AND METABOLIC RESEARCH
Volume 32, Issue 3, Pages 107-109Publisher
GEORG THIEME VERLAG
DOI: 10.1055/s-2007-978600
Keywords
leptin; hyperphagia; diabetic mice; tumor necrosis factor
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Zinc has an antihyperglycemic effect. Zinc can also influence the production of leptin, a satiety factor that reduces appetite and blood sugar level. In this study, we investigated the effect of zinc supplementation on food intake and circulating leptin and glucose concentrations in streptozotocin-induced diabetic mice. Male diabetic mice received zinc supplementation (20 ppm) from drinking water for two weeks. The results showed that zinc treatment did not affect body weight gain, body fat content or food intake in these diabetic mice. However, zinc supplementation markedly ameliorated the hyperglycemia of diabetic mice. After zinc treatment, serum leptin concentrations tended to increase in the diabetic mice. This study suggests that zinc is a mediator of leptin production.
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