Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 11, Issue 2, Pages 59-65Publisher
KARGER
DOI: 10.1159/000017215
Keywords
vascular dementia; depression; microinfarction
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The neuropathological substrates of dementia and depression were evaluated in 30 patients with cerebrovascular disease and significant cognitive impairment (VaD), with a particular focus on patients with small infarct volumes (<15 ml). VaD patients with small infarct volumes had a similar degree of cognitive impairment to those with larger infarct volumes (>15 ml) but were significantly more likely to be depressed and to have areas of microinfarction. A review of individual cases with small infarct volumes suggested that the combination of microinfarction, diffuse white matter disease and perivascular changes, or the overlap of neurodegenerative pathologies and microvascular changes were particularly important. Microinfarction was also significantly associated with major depression. Copyright (C) 2000 S. Karger AG, Basel.
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