Journal
MECHANISMS OF DEVELOPMENT
Volume 91, Issue 1-2, Pages 143-152Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(99)00287-7
Keywords
primordial germ cells; cadherins; cell migration; gonadogenesis; flow cytometry; RT-PCR; immunohistochemistry; green fluorescent protein; transgenic mice
Categories
Funding
- NICHD NIH HHS [HD00850-10, HD33440-01] Funding Source: Medline
Ask authors/readers for more resources
Primordial germ cells (PGCs) are the founder cells of the gametes. In mammals, PGCs migrate from the hindgut to the genital ridges, where they coalesce with each other and with somatic cells to form the primary sex cords. We show here that, in both sexes, PGCs express P- and E-cadherins during and after migration, and N-cadherin at post-migratory stages. E-Cadherin is not expressed by PGCs whilst in the hindgut, but is upregulated as they leave. Blocking antibodies against E-, but not P-cadherin cause defective PGC-PGC coalescence, and in some cases, ectopic PGCs. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available